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Growth Factors – Platelet Rich Plasma
Application on the scalp

What is Plaque Rich Plasma?

Platelet-rich plasma (PRP) is a platelet concentrate obtained from the patient’s own centrifuged blood, containing proteins, especially growth factors (GF), responsible for coagulation, healing, and tissue regeneration.

How does platelet-rich plasma work?

Naturally, when tissue ruptures, (a cut, for example), so-called platelet aggregation occurs, in other words, the platelets clump together to form a stopper (“platelet stopper”) that closes the wound and prevents blood loss.

During aggregation or having contact with the connective tissue, the membrane cells of the platelet are activated by releasing the contents of their Alpha Granules, these are growth factors. When these growth factors come together with cell membrane receptors, the cell is either activated or inhibited in its functions.

There are several types of growth factors, each of them responsible for a function in different tissues. Thus, growth factors regulate and therefore play a majorly important role in appearance, production diminishing with age and becoming less active

On the other hand, growth factors intervene as external cell cycle control:

They stimulate cell migration and proliferation by increasing the rate of mitosis (Cell multiplication) of all cells with suitable receptors, cell differentiation and apoptosis (programmed cell death). They also increase cell metabolism, by stimulating cellular processes for the regeneration of tissue and wound healing (repair, remodeling).

A nivel capilar mejora la vascularización del folículo piloso, promoviendo el crecimiento e incrementa el tamaño del folículo y de la hebra pilosa.

Takakura et al Demonstrated that PDGF (platelet-derived growth factor) are related to the Epidermis-follicle interactions and with the mesenchymal interaction (Embryonic tissue) are necessary for the formation of the hair canal and with the growth of the dermal mesenchyme. In 2001 Yano, et al identified VEGF (vascular endothelial growth factor) as

The most important mediator of hair follicle growth and its cycles, providing the first direct evidence that improved follicular vascularization promotes growth and increases the size of the follicle and hair strand.

Physiologically the hair follicle provides a certain number of hairs throughout our life, as the follicle wears out, the caliber and hair coloration decreases, then the hair appears miniaturized, finer and bleached.

If we consider that when the follicle has been miniaturized to the point of being unobservable to the naked eye, it still has the potential to retransform and generate long hair strands, “and that if” the hair is composed practically by the same type of stem cells in the area of ​​the protuberance (Area of ​​the follicle with potential to form a new hair), then we must assume miniaturized hair may be reversed.

How it is performed?

First, there is the extraction of approximately 16 cc of the patient’s blood. It is then processed by centrifugation to get 8cc of Rich Plasma in Platelets.

It will then be applied in the form of multiple micro-punctures (nappage), by way of mesotherapy and filling out wrinkles where needed to create volume. A thin film of PRP will be left on the face for 10 minutes to act topically, further enhancing the appearance of the skin.


Los resultados en el estudio realizado por Greco et al, revelaron un engrosamiento de la hebra pilosa de un 9,7% a los 4 meses y de un 6,1% a los 8 meses.

How long does the entire process take?

Approximately 30 minutes between extraction and infiltration of PRP in the tissue.

It is painful?

Since micro punctures are performed, slight discomfort may occur but can be minimized with the topical application of anesthetic cream (EMLA) beforehand (20 minutes).

How will it look after the consultation?

You may notice slight redness of the treated area.

Will I have trouble the next day?

As on any occasion where punctures are performed, a small bruise which fades quickly, specifically thanks to the infiltration of growth factors.

When will I notice the effect?

By the next day you will already notice more luminous skin. Due to the mechanism of growth factors, the effect will be more noticeable as time goes by and with the number of applications having significant effects on the texture and structure of the skin.

How many sessions will be needed?

When starting the treatment to revitalize the skin, it is advisable to perform 3 sessions every 2 weeks. In the case of mesotherapeutic treatment and filling to treat wrinkles, it is advisable to perform 2 sessions 3 months apart. Checkups will be held approximately once a year unless otherwise indicated.